Fig. 1
From: The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
Structures and functional regions of steroid receptor coactivators. (A) The domain structure diagram of steroid receptor coactivators. (B) The functional regions of steroid receptor coactivators. Three homologous SRC proteins (i.e., SRC-1, SRC-2, and SRC-3) have similar molecular weights and protein domains, including bHLH-PAS, NRID AD1, and AD2 domains. The LXXLL motifs located on the NRID are responsible for direct interaction with NRs, and the ADs are primarily responsible for promoting the formation of transcriptional complexes by recruiting secondary coregulatory factors, including p300, CBP, PRMT1, and CARM1