Fig. 7

Pramex1 and Pramel1 exhibit compensatory effects on the fecundity of sKO female mice. A Litter size for female mating tests (n = 7 ~ 8). Data were expressed as mean ± SEM. Significance was assessed among the four mattings (WT♀ x WT♂, Pramex1 sKO♀ x WT♂, Pramel1 sKO♀ x WT♂, female dKO♀ x WT♂ mice). B IFS for PRAMEX1 and PRAMEL1 in ovary cross-section. Bar = 50 µm. C The litter size of different mattings suggests that the fecundity of both male and female Pramex1/Pramel1 dKO mice was decreased (n = 7 ~ 8). Significance was assessed among the four mattings (WT♀ x WT♂, WT♀ x dKO♂, Pramel1 sKO♀ x dKO♂, dKO♀ x dKO♂ mice) which producing 29, 30, 31, 40 litters from 7, 7, 8, 11 breeding pairs, respectively. Data were expressed as mean ± SEM. Values that do not share a common superscript (a–c) were found to differ significantly (P < 0.05)