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Table 1 Summary of cardiac progenitor cells populations.

From: Cardiac progenitor cell therapy: mechanisms of action

Cell type (or phenotype)

Markers used for isolation and characterization

Source

Cardiac colony-forming unit fibroblasts (cCFU-Fs)

Sca-1pos, PDGFR-αpos, CD31neg, c-Kitlow, CD45neg, FLK1neg, CD44pos, CD90pos, CD29pos and CD105pos

mouse, human

Cardiac side population cells (CSPCs)

CD34pos, CD45pos, Abcg2pos, Sca-1pos, c-kitpos, NKX2–5neg, GATA-4neg

mouse, human

Cardiosphere-derived cells (CDCs)

CD31pos, CD105pos, CD34pos, CD45pos, Abcg2pos, Sca1pos, c-kitlow

mouse, rat, dog, pig, human

c-kitpos eCSCs

CD34neg, CD45neg, Sca-1pos, Abcg2pos, CD105pos, CD166pos, GATA-4pos,

NKX2–5pos/neg or low, MEF2Cpos, VEGFR-2neg, CD31neg,

mouse, rat, pig, human

Epicardium-derived progenitor cells (EPDCs)

CD34pos, c-Kitpos/neg, CD44pos, CD90pos, CD105pos, CD46pos, WT-1

mouse, human

Isl1pos CPCs

(embryonic/fetal)

CD31neg, Sca-1neg, c-kitneg, GATA-4pos, NKX2–5pos

mouse, rat, human

Sca1pos CPCs

Sca-1pos, CD105pos, CD34neg, CD45neg, FLK1neg, c-kitpos/neg, GATA-4pos, NKX2-5pos/neg, MEF2Cpos; CD133neg

mouse, human