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Table 1 Correlation between METTL3 and CYP19A1 expression with clinical characteristics

From: METTL3 drives NSCLC metastasis by enhancing CYP19A1 translation and oestrogen synthesis

  

METTL3 expression

  

CYP19A1

expression

   

Characteristics

Total (n = 84)

Low (n = 25)

High (n = 59)

χ2

P value

Low (n = 26)

High (n = 58)

χ2

P value

Gender

 Male

 Female

   

0.04314

0.8355

  

1.951

0.1624

66

20

46

  

18

48

  

18

5

13

 

8

10

  

Age at surgery

 ≥ 60

 ＜ 60

   

0.7921

0.3735

  

0.1442

0.7042

33

8

25

  

11

22

  

51

17

34

  

15

36

  

TNM stage

   

0.2847

0.5936

  

14.44

0.0001

 I-II

30

10

20

  

17

13

  

 III

54

15

39

  

9

45

  

TNM stage: T

   

0.1452

0.7032

  

6.641

0.0100

 T1-T2

58

18

40

  

23

35

  

 T3-T4

26

7

19

  

3

23

  

TNM stage: N

   

7.999

0.0047

  

10.36

0.0013

 N0

20

11

9

  

12

8

  

 N1-3

64

14

50

  

14

50

  

Tumor histology

   

0.2739

0.6007

  

2.553

0.1101

 SQC

44

12

32

  

17

27

  

 ADC

40

13

27

  

9

31

  
  1. Note P values were derived from the χ2 test; P values in bold font indicate statistically significant differences. SQC represents squamous cell carcinoma and ADC represents adenocarcinoma. TNM staging is based on the eighth edition of UICC/AJCC lung cancer stage classification (2017)
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Cell & Bioscience

ISSN: 2045-3701

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