Table 2 The endogenous changes of OXT in stress
From: Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Species, gender | Stress type | Outcome | References |
|---|---|---|---|
Mice, M&F | Chronic variable stress | Basal CORT and PVN immunoreactivity↑ CRH and OXT mRNA in the PVN↑ Without anxiety behavior | [170] |
Mice, M&F | Chronic neuropathic pain | OXT concentration in PVN and elevated expression of OXTR in ACC | [163] |
Rat, M | Restraint stress | Arterial pressure, heart rate, plasma OXT↑ Using OXT antagonist attenuates tachycardic responses | [101] |
Rat, F | Psycho-social stress | OXT release in PVN↑ | [171] |
Human, F Mice, M | PTSD | Blood OXTR mRNA concentrations in human↑ Prefrontal cortical OXT and OXTR mRNA in mice↑ HPA axis response relies on regulation of OXTR expression | [157] |
Human, M&F | PTSD | Plasma OXT in men and women ↓ | [134] |
Human, F | Acute stress (emotionally stressful video) | Negative emotion and salivary cortisol ↑ Baseline OXT predicts stress response | [172] |