Table 1 The efficacy of exogenous administration of OXT in different stress
From: Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Species, gender | Stress type | Dosage Regimen | Index change | Outcome | References | |
|---|---|---|---|---|---|---|
Rat, M | Chronic stress | Oral treatment, 10 IU/400 μl, 14 days | NAT, VMAT2↑ catecholamine↓ | Attenuated adrenal gland atrophy | [157] | |
Rat/mice, M&F | Acute restraint stress | I.c.v injection in PVN, rats1 nmol/2 μl; mice 0.5 nmol/2 μl | OXTR↑ Crf mRNA, CRF, CREB, CRTC3↓ | Regulating stress response | [158] | |
Rat, M | Early-life stress Restraint stress | I.c.v injection in mPFC and PVN, 1 µg/µL | Duration in central zone, open arm ratio ↑ | Anxiolytic effect | [9] | |
Rat, M&F | Mild stress | I.c.v injection, 10 ng/h, duration 14 days | CRFR2α form in CSF ↑ | Anxiety-like behavior | [99] | |
Rat, M | Tail-shock stress | Intranasal administration, 1 mg/ml, 200μL | fEPSP, LTP↑ | Synaptic plasticity↑ | [159] | |
Rat, M | PTSD | Intranasal administration, 1 μg/μL, 2 × 10 μL | CRHR1 in mPFC↓ | Prosocial contacts↑ | [64] | |
Mice, M | Early life stress | Intranasal administration, 2μL, 12 IU/kg | Serum CORT↓ | Paw-licking behaviour↑ Self-grooming↑ | [160] | |
Mice, M | Chronic subordinate colony housing stress | I.c.v injection, 1 ng/h, 10 ng/h | OXTR(high dose) ↓ ACTH sensitivity ↓ | Anxiety (high dose) Inhibit hyper-anxiety (low dose) | [100] | |
Mice, M&F | Acute restraint stress | I.c.v injection, 1.25 or 2.5 μg/0.5 μL | Adult hippocampal neurogenesis↑ | METH addiction, stress response↓ | [161] | |
Mice, M&F | Acute & chronic Social defeat | Intranasal administration, 8 IU/kg | Social interaction (F)↓ social interaction (M)↑ | Anxiolytic in male | [162] | |
Mice, M&F | Chronic neuropathic pain | I.c.v injection, 100 μM/0.5μL | Pre-LTP in ACC↓ action potential, resting membrane potential↑ | Attenuates neuropathic pain and emotional anxiety | [163] | |
Prairie voles, F | Chronic social isolation | Subcutaneous injection, 20 μg/50 μl, 14 days | / | Sucrose preference↑ Immobility in FST↓ | [164] | |
Prairie voles, F | Chronic social isolation | I.p injection, 0.05 mg/kg, 0.5 mg/ml | Serum CORT↓ | Oxidative damage, Telomere degradation↓ Sucrose preference↑ | [165] | |
Prairie voles, F | Mild stress | I.c.v injection in PVN, 10 ng/nl | PVN GABA activity↑ HPA axis activation↓ | Anxiolytic effect | [166] | |
Marmoset, M&F | Chronic social isolation | Intranasal administration, 25 IU | Serum CORT in female↓ | Modulate HPA-axis response via prosocial behavior | [89] | |
Human, M | Acute psychosocial Stress | Intranasal administration, 24 IU | Amygdala–hippocampal functional connectivity ↑ | Stress reactivity and sensitivity ↓ | [167] | |
Human, M | Acute psychosocial Stress | Intranasal administration, 24 IU | Limbic deactivations↑ | Stress reactivity↑ | [168] | |
Human, F | Experimentally induced pain | Intranasal administration, 24 IU | Heart rate variability↓ | The salience of social proximity↑ | [169] | |