Fig. 1
From: Animal models of primary biliary cholangitis: status and challenges
Advantages and disadvantages of genetically modified models of primary biliary cholangitis (PBC). Six genetically modified mouse models are available (dnTGF-βRII, IL-2Rα−/−, NOD.c3c4, AE2a,b−/−, ARE-Del−/−, and Scurfy mice). Each animal model has advantages and disadvantages (left). Animal models of PBC have the following characteristics: female predominance, antimitochondrial antibody production, lymphocytic inflammation, bile duct destruction, granuloma formation, eosinophilia, and liver fibrosis (right)