Skip to main content
Fig. 9 | Cell & Bioscience

Fig. 9

From: Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Fig. 9

A possible hypothesis that ERVWE1 impaired 5-HT neuronal plasticity by posttranscriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms in schizophrenia. ERVWE1 reduced the global m6A level depending on ALKBH5 demethylation, contributing to HTR1B upregulation and activating the downstream signaling pathway, which led to a decrease in 5-HT neuronal dendrite complexity and spine density in schizophrenia

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us