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Fig. 8 | Cell & Bioscience

Fig. 8

From: Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Fig. 8

ERVWE1-influenced 5-HT neuronal plasticity was mediated by ALKBH5. A-F The complexity of 5-HT neurons in the ERVWE1-expressed and empty plasmid groups after co-transfection with ALKBH5 deficiency or control vectors by Sholl analysis. Scale bars = 25 μm. A 5-HT neuron morphology. B, C Sholl intersection numbers (n = 9). D Total branching length (n = 9). E The average length of branching (n = 9). F The area of soma (n = 9). G–J The spine density of 5-HT neurons in pcDNA3.1 + siNC, pcDNA3.1-ERVWE1 + siNC, pcDNA3.1-ERVWE1 + siALKBH5 groups. G The diameter of dendrites of 5-HT neurons. Scale bars = 5 μm. H Total spine density (n = 15). I Each subtype’s spine density (n = 15). J The percentage of spine density in four types (n = 15). Data are mean ± SD. Statistical analysis: one-way ANOVA (ns p > 0.05, **p < 0.01, ***p < 0.001)

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Cell & Bioscience

ISSN: 2045-3701

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