Skip to main content
Fig. 5 | Cell & Bioscience

Fig. 5

From: Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Fig. 5

HTR1B participated in ERVWE1-regulated 5-HT neuronal plasticity. A, B The relative fluorescence intensity of Arc. Scale bars = 60 μm. C The morphology of 5-HT neurons. Scale bars = 25 μm. D–H The dendrites branching number, total number, total length, average length, and soma area of 5-HT neurons after co-transfection with ERVWE1 and siHTR1B (n = 9). I–L The spine density in the pcDNA3.1 + siNC, pcDNA3.1-ERVWE1 + siNC, and pcDNA3.1-ERVWE1 + siHTR1B groups. I, J Total spine density (n = 15), Scale bars = 10 μm, K Each subtype’s spine density (n = 15), L Percentage density of each spine subtypes (n = 15). Data are mean ± SD. Statistical analysis: one-way ANOVA (ns p > 0.05, **p < 0.01, ***p < 0.001)

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us