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Fig. 4 | Cell & Bioscience

Fig. 4

From: Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Fig. 4

ERVWE1 decreased 5-HT neurons complexity and spine density. A Morphology of 5-HT neurons stained with MAP2 (red) in control and ERVWE1 groups. Scale bars = 25 μm. B–F The Sholl analysis of 5-HT neurons in control and ERVWE1 groups. B The intersection numbers (n = 9), C Total dendritic branching numbers (n = 9), D Total dendritic length (n = 9), E Average dendritic length (n = 9), and F soma area (n = 9). G–K ERVWE1 decreased spines density of 5-HT neurons. G Confocal images of 5-HT neurons transfected with control and ERVWE1 expressed vectors, Scale bars = 40 μm / 10 μm, H Total spine density (n = 15), I A schematic diagram to show four types of spines, J Spine density of each subtype (n = 15), and K Percentage of total spine density in four subtypes (n = 15). Data are mean ± SD. Statistical analysis: Student’s t-test (ns p > 0.05, **p < 0.01, ***p < 0.001)

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Cell & Bioscience

ISSN: 2045-3701

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