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Fig. 1 | Cell & Bioscience

Fig. 1

From: Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Fig. 1

Higher expression of HTR1B in schizophrenia was associated with ERK2 and m6A modification in GSE53987. A, B Partial visualization of GO (Gene Ontology) analysis for DEGs, A GOCC analysis, B GOBP analysis, X-axis represents gene ratio, Y-axis represents different ontologies, the circle color represents p-value and the circle size shows count number. C KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis for DEGs. D Boxplot of HTR1B expression in the prefrontal cortex (BA46) of schizophrenia patients (n = 15) and healthy controls (n = 19), p-value by Wilcoxon (Mann-Withney). E Correlation heat map analysis among 5-HT receptors, raf1 and ERK2, red and blue represent positive and negative correlation, *p < 0.05 by Spearman. F Correlation matrix analysis of HTR1B and m6A modification-related genes, red represents positive and blue represents negative correlation, *p < 0.05 by Spearman. The correlation coefficients are shown in the corresponding grids. Data are mean ± SD

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Cell & Bioscience

ISSN: 2045-3701

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