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Table 2 Results of the MR study testing causal association between genetically predicted myasthenia gravis and gut microbiota

From: Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study

Gut microbiota

Number of SNPs

Beta

P

OR (95% CI)

P for heterogeneity test

P for MR-Egger intercept

P for MR-PRESSO (0 outliers)

Genus Barnesiella

 IVW

4

− 0.057

0.008

0.945 (0.906–0.985)

0.537

0.526

0.660

 MR Egger

4

− 0.010

0.895

0.990 (0.871–1.126)

0.450

  

 Weighted median

4

− 0.056

0.039

0.946 (0.897–0.997)

   

 Simple mode

4

− 0.059

0.189

0.942 (0.880–1.009)

   

 Weighted mode

4

− 0.058

0.152

0.943 (0.888–1.001)

   
  1. SNPs single nucleotide polymorphisms, OR odds ratio, IVW inverse variance weighted
  2. The summary data on gut microbiota is derived from a genome-wide association study involving 18,340 individuals. Data on myasthenia gravis were sourced from Finngen Research Project, comprising 426 cases and 373,848 controls
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Cell & Bioscience

ISSN: 2045-3701

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