Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study

Cell & Bioscience

Table 1 Results of the MR study testing causal association between genetically predicted gut microbiota and myasthenia gravis

Gut microbiota	Number of SNPs	Beta	P	OR (95% CI)	P for heterogeneity test	P for MR-Egger intercept	P for MR-PRESSO (0 outliers)
Family Clostridiaceae1
IVW	10	− 0.857	0.023	0.424 (0.202–0.899)	0.528	0.595	0.600
MR Egger	10	− 1.429	0.230	0.239 (0.028–2.066)	0.458
Weighted median	10	− 0.491	0.343	0.612 (0.222–1.689)
Simple mode	10	− 0.328	0.721	0.720 (0.126–4.128)
Weighted mode	10	− 0.344	0.681	0.709 (0.145–3.470)
Family Defluviitaleaceae
IVW	11	− 0.622	0.048	0.537 (0.290–0.995)	0.312	0.728	0.409
MR Egger	11	− 0.237	0.838	0.789 (0.087–7.139)	0.246
Weighted median	11	− 0.479	0.244	0.619 (0.276–1.387)
Simple mode	11	− 0.682	0.363	0.506 (0.125–2.053)
Weighted mode	11	− 0.340	0.608	0.712 (0.202–2.059)
Family Enterobacteriaceae
IVW	7	− 1.076	0.023	0.341 (0.135–0.865)	0.968	0.508	0.737
MR Egger	7	− 3.068	0.329	0.047(0.000–12.120)	0.973
Weighted median	7	− 1.063	0.081	0.345 (0.105–1.138)
Simple mode	7	− 1.336	0.152	0.263 (0.053–1.296)
Weighted mode	7	− 1.321	0.159	0.267 (0.053–1.335)
Unknown genus
IVW	13	− 0.899	0.008	0.407 (0.209–0.793)	0.242	0.759	0.174
MR Egger	13	− 1.199	0.263	0.302 (0.041–2.209)	0.189
Weighted median	13	− 0.592	0.195	0.553 (0.226–1.335)
Simple mode	13	− 0.469	0.523	0.626 (0.155–2.532)
Weighted mode	13	− 0.561	0.389	0.571 (0.167–1.954)
Genus Lachnoclostridium
IVW	13	0.888	0.039	2.431 (1.047–5.647)	0.168	0.287	0.209
MR Egger	13	2.399	0.118	11.017 (0.688–176.305)	0.190
Weighted median	13	1.043	0.042	2.838 (1.039–7.755)
Simple mode	13	1.008	0.251	2.741 (0.533–14.092)
Weighted mode	13	1.176	0.195	3.241 (0.604–17.402)

SNPs single nucleotide polymorphisms, OR odds ratio, IVW inverse variance weighted
The summary data on gut microbiota is derived from a genome-wide association study involving 18,340 individuals. Data on myasthenia gravis were sourced from Finngen Research Project, comprising 426 cases and 373,848 controls

ISSN: 2045-3701