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Fig. 7 | Cell & Bioscience

Fig. 7

From: Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition

Fig. 7

Graphical illustration highlighting our findings that CAFs promote NSCLC invasion and metastasis via MSI2-driven IL-6 secretion. MSI2 is upregulated in CAFs, resulting in IL-6 secretion, which mediates the tumor promoting effect of CAFs via the activation of EMT in NSCLC cells, resulting in tumor metastasis. By contrast, depletion of MSI2 in CAFs inhibited paracrine IL-6, which limits EMT in NSCLC cells, thus preventing NSCLC spreading

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Cell & Bioscience

ISSN: 2045-3701

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