Fig. 6
From: Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas
Frameshift mutation resulting in premature stop codons is also a potential therapeutic target. Proliferation activities of AML12 cells expression Lenti-CMV-MCS control virus (MCS), FGFR2, FGFR2-BICC1 fusion and FGFR2 I548Wfs*8 mutant are shown (A). Representative images of transwell migration and average numbers of migrated cells expressing above three clones (B), the scale represents 100 µm. Representative images of invasion and average colonies of invasion cells expressing above three clones in AML12 cells are shown (C). Capability of FGFR2 I548Wfs*8 rendering RBE cells sensitive to BGJ398 (D)