Fig. 5

Suppression of pro-inflammatory cytokines and IFNG responses mediated by miR-181a are associated with worse PARPi responses. A–E Quantification of STING (A), IL6 (B), IFNB (C), IL12A (D), and IL12B (E) mRNA levels in empty vector (CTRL) and STING-OV HCC1937 cell line by RT-qPCR (Student’s t-test). B–I Correlation between miR-181a levels and IL6 (F), IL12B (G), and IFNG (H) mRNA levels; and IFNG response score (I) in TNBC in the TCGA BRCA database (Pearson’s correlation coefficient). J–M Correlation between STING mRNA levels and IL6 (J), IL12B (K), and IFNG (L) mRNA levels; and IFNG response score (M) in TNBC in the TCGA BRCA database (Pearson’s correlation coefficient). N Correlation between IFNG response score and STING mRNA levels in the pretreatment biopsy tissues from patients enrolled in the I-SPY2 trial (Pearson’s correlation coefficient). O Comparison of IFNG response score in the pretreatment biopsy tissues of patients who underwent durvalumab/olaparib/paclitaxel (DOP) and had complete response (CR) or non-CR, in the I-SPY2 trial (Student’s t-test). *p < 0.05, **p < 0.01, ***p < 0.001