Fig. 2
From: A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
Genetic screen identifies modifiers of APOL1-G1 induced renal toxicity. A Schematic illustration of genetic screen designed to identify genetic modifiers of APOL1-RA (G1) induced renal toxicity, with adult fly hatching lethality as read-out. Hand-GFP, nephrocyte marker; Mhc-ANF-RFP, nephrocyte function read-out based on ANF uptake; Dot-Gal4/Cyo, nephrocyte-specific driver with CyO balancer chromosome; UAS-APOL1-G1, APOL1-G1 transgene; UAS-GeneX-RNAi, UAS-based RNAi transgenic lines. B Top 10 genes found to increase adult fly hatching lethality caused by APOL1-G1 compared to lethality observed for APOL1-G1 alone (~ 5%; not shown) or GeneX-RNAi by itself. Genes encoding SNARE proteins have been highlighted. DIOPT, DRSC Integrative Ortholog Prediction Tool