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Fig. 5 | Cell & Bioscience

Fig. 5

From: Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction

Fig. 5

Results of the in vivo safety study. a Immunofluorescence staining of OCT4 and KI67 for iCEC products. Nuclei were stained with DAPI. Scale bars: 50 μm. b qPCR analysis of POU5F1 in iCEC products spiked with different concentrations of hESCs. The data are represented as quantification cycle values (Cq) (mean ± SD, n = 9) and normalized to GAPDH. c Tumorigenicity study of hESCs (number of animals = 10) and iCEC products (number of animals = 20). d Representative images of hematoxylin and eosin staining showing the endoderm (respiratory epithelium), mesoderm (cartilage) and ectoderm (pigmented retinal epithelium) from a single teratoma in the subcutaneous space of NOG mice injected with hESC lines (CB0019). Scale bars: 100 μm

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Cell & Bioscience

ISSN: 2045-3701

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