Fig. 2
From: Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
Activation of MCs in CRC.
a. CIBERSORT-based analysis-generated heatmap showing the difference in the proportion of activated and resting MCs between NC and CRC in 10 bulk RNA-seq cohorts of CRC. Red indicates a higher proportion in CRC, while blue indicates a lower proportion in CRC. b. DEGs between NC MCs and CRC MCs from the GSE164522, GSE178341, and 5-cohort datasets (top). Venn diagram of upregulated DEGs in CRC MCs (bottom). Screening criteria are indicated by the dotted lines. c. Gene Ontology Biological Process (GO BP) enrichment analysis of upregulated DEGs in CRC MCs. d. Heatmap showing the expression of cytokine and growth factor, protease and histamine, lipid mediator, and various receptor-related genes across different major cell types (5-cohorts). e. Heatmap showing the expression of cytokine and growth factor, protease and histamine, lipid mediator, and various receptor-related genes in MCs (NC vs. CRC) (5-cohorts). The tissue type is indicated by the color above the heatmap. f. Heatmap showing the expression of cytokine and growth factor, protease and histamine, lipid mediator, and various receptor-related genes in MCs (NC vs. CRC) (GSE178341)