Fig. 6
From: c-Jun as a one-way valve at the naive to primed interface
c-Jun functions as a lock to maintain closed naïve enhancers and represses the PNT. A model depicting the chromatin accessibility dynamics in naive to primed transition (NPT) and primed to naive transition (PNT). During NPT naïve enhancers were closed and bound by c-Jun. c-Jun functions as a lock to keep the naive enhancers in a closed state. However, if c-Jun is removed, the lock is loosened and the closed naive enhancers are primed and ready to recruit key naive-specific TFs to reactivate the naive gene regulatory network during the primed EpiSC to naive ESC transition