Fig. 2
From: Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
The main function of IMCs in intestinal homeostasis. Intestinal mesenchymal cells play an important role in maintaining intestinal homeostasis. The main functions of fibroblasts and pericytes are maintaining epithelial homeostasis, stem cell niche, vascular function and ECM. Meanwhile, CAFs and myofibroblasts can promote inflammation, cell proliferation, angiogenesis, invasion and migration