Table 1 Modulates glycolysis-cholesterol axis-related drugs in combination with immunotherapy

Glycolysis

Non-steroidal anti-inflammatory drug (NSAID)

T cells

Anti-PD1

[64, 143]

Rapamycin

TAMs

Anti-PD-L1

[131, 133]

Carbonic anhydrase XII (CA12) inhibitor

Tumor-infiltrating macrophages

Anti-PD-1

[134]

Cholesterol

5-azacytidine

TAMs and T cells

//

[87]

Simvastatin

PD-L1 expression

Anti-PD-L1

[156]

LXR agonist

MDSCs

Anti-PD-L1

[94]