Fig. 6
From: Neuronal MHC-I complex is destabilized by amyloid-β and its implications in Alzheimer’s disease
Aβ-resistance of MHC-I inhibited the Aβ-mediated downregulation of NCAM1 signaling. A–C Representative images of primary neurons expressing green-fluorescent protein (GFP), GFP/HLA-A2.1, and GFP/SCT-HLA-A2.1 in the presence or absence of treatment with oAβ for 8 days in vitro (A). Quantification of dendrite numbers (B) and the process lengths (C) in mock- and Aβ-treated primary neurons expressing GFP, GFP/HLA-A2.1, and GFP/SCT-HLA-A2.1 (n = 3, at least 35 segments per sample; two-way ANOVA with Tukey’s post-hoc comparisons test). Scale bar: 20 µm. The data are presented as the mean ± SEM (N.S., not significant; *P < 0.05, **P < 0.001, ***P < 0.005)