Fig. 7

Mettl1 overexpression rescues the decreased neurogenesis and cognitive deficit in APP/PS1 mice. (A) Representative fluorescence images for Mettl1 in the NSCs of hippocampus. Scale bar, 200 μm. (B-E) Representative fluorescence images and quantification for BrdU and DCX after retrovirus-mediated Mettl1 overexpression. Scale bar, 250 μm. ***P < 0.001, **P < 0.01. (F) The escape latency in the navigation test. *P < 0.05 compared with AD + vector. (G) Quadrant time (%) in the probe test. **P < 0.01. (H) The number of target crossings where the platform had been located in the probe test. ***P < 0.001, **P < 0.01. (I) The average swimming speed among the groups. (J) Representative swimming paths in each quadrant during the probe trial. n = 8 mice per group. Data are represented as the mean ± SEM. AD, Alzheimer’s disease (APP/PS1 mice); OE-Mettl1, overexpressing Mettl1