Fig. 6

Mettl1 knockdown elicits reduced neurogenesis and cognitive impairment in mice. (A-D) Representative fluorescence images and quantification for BrdU and DCX after Mettl1 shRNA retrovirus infection. Scale bar, 250 μm. ***P < 0.001 compared with vector (control). (E) The escape latency in the navigation test. **P < 0.01 compared with vector (control). (F) The number of target crossings where the platform had been located in the probe test. *P < 0.05 compared with vector (control). (G) Quadrant time (%) in the probe test. **P < 0.01 compared with vector (control). (H) Representative swimming paths in each quadrant during the probe trial. (I) The average swimming speed between the two groups. n = 8 mice per group. Data are represented as the mean ± SEM. Sh-Mettl1, shRNA Mettl1