Fig. 10

The diagram illustrates the role of astaxanthin in the development of senescence and apoptosis of neurons. ROS production increased after Aβ25-35 treatment. In vivo experiments, ROS can reduce the expression of Bcl-2 and increase the expression of Bax in the hippocampus of mice, which can promote the senescence and apoptosis of neurons, accelerate the process of brain aging and AD, and reduce cognitive function. In vitro experiments, ROS reduced mitochondrial function, senescence, and apoptosis of PC12 cells. Astaxanthin and SIRT1, PGC-1α have strong antioxidant effects, which can resist cell senescence and apoptosis caused by oxidative stress, improve mitochondrial function, and improve the cognitive function of mice