Fig. 1

The mice in the control, Aβ, Aβ + AST, and Aβ + AST + NAM groups were treated with the corresponding reagents (n = 20/group). After successful modeling, the Morris water maze test was performed on each group of mice. A Schematic diagram of the experiment process. B Duration of each group of mice. C Swimming distance of each group of mice. D Swimming speed of each group of mice. E The number of times that mice in 4 groups crossed the platform in the probe experiment. *P < 0.05, Control group vs. Aβ group and Aβ + AST + NAM group. #P < 0.05, Aβ + AST group vs. Aβ + AST + NAM group. &P < 0.05, Aβ + AST group vs. Aβ group. F The time in quadrants of 4 groups of mice. *P < 0.05, Control group vs. Aβ group and Aβ + AST + NAM group. #P < 0.05, Aβ + AST group vs. Aβ + AST + NAM group. &P < 0.05, Aβ + AST group vs. Aβ group. G: The escape latency of the four groups of mice in the positioning navigation experiment