Fig. 6

Interaction of C99 with cholesterol at the luminal/extracellular membrane face. In the j.m. region, both H-bonds and hydrophobic interactions between the cholesterol hydroxyl or aromatic A-ring and surrounding amino acids may be involved, as is indicated by red arrows. The exact arrangement depends on many factors, including the lipid environment, bilayer thickness, pH, and the tertiary and quaternary structure of the peptide. Adjusted according to [202, 310, 315]