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Fig. 2 | Cell & Bioscience

Fig. 2

From: Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Fig. 2

APP dimerization. A Dimerization via the E1 domain, which can be supported by heparan sulphate (green) or Cu2+ binding. B Distinct quaternary structure of APP dimer formed by heparan sulphate binding. C Dimerization of APP, triggered by heparan sulphate interaction with the E2 domain. D After shedding the e.c. part of the molecule by β-secretase, the TM domains approach each other and can dimerize. Adjusted according to [196, 198, 199, 250, 252, 255, 256]

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Cell & Bioscience

ISSN: 2045-3701

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