Fig. 7From: Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosisProposed mechanistic model of fibrosis progression in LEPTIN−/− pig liver. Reduction of p-AMPK promotes mitochondrial autophagy. Meanwhile, activation of JAK2/STAT3 signaling pathway leads to enhanced FFA oxidation and oxidative stress. Oxidative stress drives the development liver fibrosis in LEPTIN−/− pigsBack to article page