Fig. 1
From: Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis
Generation and phenotyping of LEPTIN−/− pigs. A Body sizes of LEPTIN mutant and WT pigs. Yellow scale bar represents 1 m. B Monthly weight records of pigs. N = 3/group. C MSCT scan tomography showing body fat distribution in LEPTIN mutant and WT pigs. The red area and white arrows indicated adipose tissue. The scale bar represents 50 mm. D Blood glucose, plasma triglyceride and plasma total cholesterol levels in LEPTIN mutant and WT pigs. E Plasma insulin levels in LEPTIN mutant and WT pigs. F HOMA-IR results evaluating insulin resistance for pigs at different ages. G IVGTT assay to assess blood glucose regulation. N = 3/group. The bars represent the mean ± SD; *P < 0.05, **P < 0.01, and ***P < 0.001; NS, non-significant