Fig. 6

Differential expression of transcription factors with motifs enriched in cis co-accessible networks. a, Table showing number of CCANs identified for each snATAC-seq cluster as well as the number of enriched transcription factor (TF) motifs corresponding to TFs identified as DEGs with |Log₂FC|> 0.2 in our snRNA-seq analysis within both unidirectional and mixed CCANs. The specific identified TFs and corresponding motif fold enrichment values are indicated in brackets where applicable. b and c, Sequence logos for indicated enriched motifs in unidirectional (b) and mixed (c) CCANs associated with labeled DEG TFs, along with violin plots of normalized snRNA-seq expression data split by normal control (NC) and LOAD groups for the corresponding TFs for each applicable cluster. Also indicated are adjusted p-values (FDR) and log₂FC for TF gene expression data. Motifs are presented from left to right in decreasing order of enrichment for each cluster. Where multiple motifs corresponded to the same TF, the most highly enriched motif is shown