Fig. 9

Schematic model of Menin recruiting transcriptional factors into promoters of Fabps, Cd36, and Gk, Pck, facilitating glucose uptake, gluconeogenesis, and mitochondrial biogenesis, while suppressing fatty acid uptake and adipogenesis through deploying the distribution ratio of activated Akt, PPARγ, and SIRT1 in the nucleus and cytoplasm. Dashed arrows indicate Menin carries its cargo and shuttles between cytoplasm and nucleus. IRS insulin receptor substrates, FFA free fatty acid, FABP fatty acid binding protein, CD36 fatty acid receptor, FoxO1 fork-head box O1, SIRT1 sirtuin 1, Pol II RNA polymerase II, GK also named Gck, glucokinase, PCK also named PEPCK, phosphoenol-pyruvate carboxykinase, PPARγ peroxisome proliferator-activated receptor gamma, PGC1α PPARγ coactivator 1α