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Fig. 2 | Cell & Bioscience

Fig. 2

From: Menin orchestrates hepatic glucose and fatty acid uptake via deploying the cellular translocation of SIRT1 and PPARγ

Fig. 2

Higher Menin expression in hepatocytes suppressed fatty acid transport by interacting with PPARγ and targeting its downstream genes. A. Menin protein was over-expressed in hepatocytes at 24 h after transfection with pcDNA3.1-mMen1 (mMen1) or an empty vector (Ctrl). The representative Western blot images are shown in the inserted panel, where ex-Menin represents exogenously over-expressed Menin, and en-Menin represents endogenous Menin. B. Downstream target genes such as Fabp3, Fabp4, Fabp5, and Cd36 were found to be inhibited upon Menin over-expression. *P < 0.05, **P < 0.01, *** P < 0.001. C. Higher Menin expression in hepatocytes inhibited the protein expression of PPARγ, FABP3, FABP4, and FABP5. D. Menin was found to interact with PPARγ in plain mouse hepatocytes via a Menin-IP assay

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Cell & Bioscience

ISSN: 2045-3701

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