Fig. 2
From: MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
Effects of K464R mutation on the structure of MRE11 protein. (A) The per-residue confidence score using AlphaFold 2 algorithm (Rank 1–5). (B) The predicted 3D structure based on the Rank 1 model confidence (pLDDT). (C) The display of Predicted Alignment Error (PAE) based on the Rank 1 model. (D) The comparison of 3D structures between MRE11WT and MRE11K464R predicted by AlphaFold 2 algorithm. (E) The position of the K464R mutation site in the secondary structure of MRE11 protein. (F) The K464R mutation site is located in the exposed region of solvent accessibility. (G) The amino acid sequence at the position of the K464R mutation is highly conserved. (H) The position of the K464R mutation site has a high degree of protein flexibility (a high relative B-value)