Fig. 7
Chromosomal mapping of DPpGCs, of PpGCs in RDC genes, and telomere related ECTR. A Chromosomal landscaping of the genomic loci giving rise to statistically significant up-DPpGCs in ALS relative to controls. B Chromosome-specific up-DPpGC enrichment scores in ALS. C Heatmap of the PpGCs derived from the 27 RDC-associated neural coding genes identified in mice [73], as detected in control and ALS samples. D Violin plots illustrating the distribution of the PpGCs from the 27 RDC-associated neural coding genes in controls and ALS. The blue circle and the red cross mark the position of the median and the mean of the distributions, respectively. E Length (log10) of repetitive telomere structures (ECTR) on eccDNA estimated for different numbers of hexanucleotide repeats in control (blue) and ALS samples (red). F Length of ECTR estimated for at least 4 hexanucleotide repeats for each control (blue) and ALS (red) sample per group. C, control samples; A, ALS samples; ECTR, extrachromosomal telomere repeats. For ALS samples, n = 9; for control samples, n = 10