Fig. 4
Coordinates of eccDNAs hotspot loci, gene coverages and relation to gene lengths. A Track plots of the loci of the six top-ranked up-DPpGCs in ALS. The genes and corresponding gene coverages represent the results in relation to controls. Each horizontal line represents the length of a gene. The green bars represent the deletion/excision loci of the eccDNA. The color bars codify the value of PpGCs in a log2 scale. B Relation between the -log10 (p-value) of the DPpGCs from ALS spinal cord and the size of the underlying gene. Red dots discriminate the 225 statistically significant up-DPpGCs in ALS from all other PpGCs (blue). The red line is the regression line of the -log10 (p-value) of the statistically significant up-DPpGCs in ALS in function of the respective gene lengths