Fig. 9

Diagnostic utility for the selected plasma-stemming exosome-based proteins in lung cancer patients with BM. A 10 soft clusters of BM. The horizontal axis indicates the initiation and progression of BM (HC, LA, and BM). The vertical axis indicates the expression of exosome-based proteins. B Nested analyses of BM versus LA and BM versus LM. ACTB, MUC5B, SNAP23, and SELL were in cluster A. C) ROC curves assessed diagnoses capability for the four BM-distinct proteins. D The area under the ROC curve of MUC5B and SELL