Fig. 6
From: Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models
Expression of NOTCH2NLC-(GGC)98 in cardiomyocytes disturbs mitochondrial respiration and energy metabolism in the heart. A QPCR validation of RNA seq-identified DEG genes in EIIa-tg and Myh6-tg and control mice. N = 3 mice per group. *P < 0.05, ****P < 0.0001 by one-way ANOVA followed by Tukey's multiple comparisons test. B Immunoblot of COX4 and Cytochrome C (Cyto C) proteins in isolated ventricular mitochondria from EIIa-tg and Myh6-tg and control mice. VDAC1 was used as a loading control. Data are presented as mean ± SEM. N = 4 per group. *P < 0.05, **P < 0.005 by one-way ANOVA followed with Tukey's multiple comparisons test. C NADH oxidase activity was measured by the NADH consumption rate of isolated ventricular mitochondria from EIIa-tg and Myh6-tg and control mice. N = 4 per group. *P < 0.05, **P < 0.005 by one-way ANOVA followed with Tukey's multiple comparisons test