Fig. 5
From: Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models
Transcriptomic profiling reveals shared and distinct molecular profiles related to cardiac dysfunction in EIIa-tg and Myh6-tg mice. A The numbers of down-regulated and up-regulated differentially expressed genes (DEGs) in the heart from EIIa-tg and Myh6-tg mice. Genes with adjusted P value (P_adj) < 0.01 and log2|FoldChange|≥ 1 were assigned as DEGs. B Heatmap of DEGs among all groups (n = 3 mice per group). C The overlapping of DEGs (both down-regulated and up-regulated) between the EIIa-tg and Myh6-tg mice. D Top 3 GO terms for DEGs exclusively identified in EIIa-tg, DEGs shared in both EIIa-tg and Myh6-tg mice, and DEGs exclusively identified in Myh6-tg. E Top 5 down-regulated GSEA pathways in Myh6-tg mice