Fig. 4
From: Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models
Mutant polyG proteins impair ventricular structure and function in the Myh6-tg mice. A Survival curve of Myh6-tg mice after tamoxifen or oil injection. B Representative 4-chamber cross-section, Hematoxylin-eosin stained at P90. Scale bar, 500 μm. C Hematoxylin-eosin staining showed infiltrating cells and vacuoles in the transgenic mice at P90. Scale bar, 40 μm. D Representative images from Masson-stained transgenic mice and control mice at P90. Scale bar, 40 μm. E Quantification of myocardial fibrotic area. **P < 0.01. F Representative M-mode echocardiography of the LV chamber. G-K Assessment of LVID at end systole and diastole (G), LVV at end systole and diastole (H), EF (%) (I), FS (%) (J) and LVPW thickness at end systole and diastole (K). N = 6 mice per group for all experiments. Data are presented as mean SEM. *P < 0.05, **P < 0.01, ***P < 0.001, using Student’s t test. LV left ventricular, LVID left ventricular internal dimension, LVV left ventricular volume, EF ejection fraction, FS fractional shortening, LVPW left ventricular posterior wall