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Fig. 8 | Cell & Bioscience

Fig. 8

From: Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation

Fig. 8

Proposed model of DCA-boosted Th17 differentiation. DCA modulates cholesterol biosynthetic pathway and increases the generation of endogenous RORγt agonists, involving zymosterol and desmosterol, leading to the recruitment of coactivators and transcriptional activation of RORγt target genes, including IL17, therefore promoting inflammation and tissue injury

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Cell & Bioscience

ISSN: 2045-3701

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