Fig. 10From: Impaired mitophagy induces antimicrobial responses in macrophages infected with Mycobacterium tuberculosisSchematic diagram. Mtb increases mROS through reduction of MMP in macrophages. Induced mROS promote the mitophagy pathway by inducing BNIP3 production through an increase in HIF1α. In contrast, mitophagy is reduced in BNIP3-deficient macrophages, resulting in elevated levels of mROS and TNF-α and inhibition of Mtb growth (Created with BioRender.com)Back to article page