New insights into the important roles of phase seperation in the targeted therapy of lung cancer

Cell & Bioscience

Table 2 Examples of advances in LLPS-based resistance against lung cancer

Targets	Types	Functions	References
Inhibitors related to the YAP phase seperation process	EVG	Disrupt the LLPS of the SRC-1 protein	[66]
	Verteporfin	Sequester YAP in the cytoplasm and disrupt the formation of YAP-containing liquid droplets in cancer cells	[63]
	Peptidomimetics	Disrupt the interaction between YAP and the transcriptional co-activator TEAD	[53]
	YAP-Tead interaction inhibitors	Disrupt the interaction between YAP and the transcriptional co-activator TEAD	[53]
Inhibitors related to the EGFR phase seperation process	SHP099	SHP2 inhibitor	[57]
Drugs affecting the process of LLPS	1,6-Hexanediol	Disrupt the LLPS process of various proteins	[25]
Delivery systems	Liposomes	Encapsulate a variety of drugs and other therapeutic agents	[64]

ISSN: 2045-3701