Fig. 1
From: New insights into the important roles of phase seperation in the targeted therapy of lung cancer
NONO condensates recruit DNA-PK and nEGFR, promote NHEJ-mediated DNA repair and induce resistance to radiation in tumors.SHP2mut induces strong LLPS to recruit SHP2WT and promote ERK activation. The formation of SGs interacts with mTOR. LLPS of EML4-ALK actives several signalings in lung cancer. Myristoylation-mediated phase separation of EZH2 activates STAT3 signaling and promotes lung tumor growth