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Fig. 7 | Cell & Bioscience

Fig. 7

From: Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice

Fig. 7

Proposed model for PGAM5 suppression in NASH. PGAM5 played differential roles in different NASH models. We found the expression of antioxidative genes were differentially regulated in mice fed with HFHF, MCS or MCD diets, and in a variety of in vitro models, which further triggered different consequences of obesity, hepatic steatosis, inflammation and fibrosis. The reason that what triggers this change was still unclear. One possibility that this difference was energy dependent and the regulations of PGAM5 on energy sensing gene mTOR may be involved. Another possibility that the differential role of PGAM5 in antioxidative response may be energy dependent or cell type dependent

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Cell & Bioscience

ISSN: 2045-3701

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