Fig. 6
From: APP family member dimeric complexes are formed predominantly in synaptic compartments
Dimer amount of the APP gene family members differs during development. A–F Protein expression analysis of dimers of the APP gene family members in mouse cortices during development. Mouse cortices of developmental stages E14, E17, P1, P3, P6, P10, P12, P30, 1 month, 6 months, and 12 months were lysed. All samples were prepared under semi-denaturing conditions for analysis on Blue Native gels. Western blot detection of APP followed with the primary α-APP C-terminal antibody Y188 (A, B), of APLP1 with the primary α-APLP1 antibody 57 (C, D) and APLP2 with the primary α-APLP2 antibody D2-II (E, F)