Fig. 10
From: APP family member dimeric complexes are formed predominantly in synaptic compartments
APP transgenic and WT mice show comparable amounts of APP dimer in the brain. A, B Mouse cortices of WT and of APP J20 transgenic mice at the age of 4 and 12 months. All samples were prepared under semi-denaturing conditions for analysis on Blue Native gels. Western blot detection of APP followed with the primary α-APP C-terminal antibody Y188. C, D Quantification of the data shown in A and B. Bars represent mean values ± SEM of dimer ratio to the total amount of the signal in %. n = 3, unpaired Student’s t test *p < 0.05, **p < 0.01, ***p < 0.001