Table 1 5-HT Receptor Summary
5-HT Receptor | Receptor Subtypes | Receptor Type | Mechanism of Action | Agonist Effect |
|---|---|---|---|---|
5-HT 1 | 1A, 1B, 1D, 1E, 1F | Gi-coupled | Decreases cAMP | Anxiolytic and anti-depressant |
5-HT 2 | 2A, 2B, 2C | Gq/11-coupled | Increases inositol phosphate and intracellular calcium | Anorexigenic and anti-psychotic |
5-HT 3 | Â | Ligand-gated ion channels | Non-selective influx of sodium and calcium | Anti-psychotic |
5-HT 4 | Â | Gs receptors | Increases cAMP | Gastroprokinetic |
5-HT 5 | 5A, 5B | Gi-coupled | Decreases cAMP | Anti-migraine and sleep promotion |
5-HT 6 | Â | Gs receptors | Increases cAMP | Anxiolytic and anti-depressant |
5-HT 7 | Â | Gs receptors | Increases cAMP | Anxiolytic and potential analgesic |